Roux-en-Y gastric bypass-associated fecal tyramine promotes colon cancer risk via increased DNA damage, cell proliferation, and inflammation
Our results collectively suggested that RYGB-associated fecal bacteria could contribute to tyramine production and tyramine increased CRC risk by increasing DNA damage, cell proliferation, and pro-inflammatory responses of the gut. Monitoring and modulating tyramine concentrations in high-risk individuals could aid CRC prognosis and management. Video Abstract.
Authors
- Nadia Guerra (ORCID: https://orcid.org/0000-0002-6159-1241)
- Jia V. Li (ORCID: https://orcid.org/0000-0002-5763-6670)
- Nigel J. Gooderham (ORCID: https://orcid.org/0000-0001-7645-8219)
- Smeeta Shrestha (ORCID: https://orcid.org/0000-0002-6560-4230)
- Julian Roberto Marchesi (ORCID: https://orcid.org/0000-0002-7994-5239)
- Maria Glymenaki (ORCID: https://orcid.org/0000-0003-4552-2438)
- Laura Rushton (ORCID: https://orcid.org/0000-0002-4643-6489)
- Mona A El-Bahrawy (ORCID: https://orcid.org/0000-0002-3414-9618)
- Sophie Curio (ORCID: https://orcid.org/0000-0002-7991-9241)
- Rachael Barry (ORCID: https://orcid.org/0000-0001-8168-3226)
- Qi Zhong (ORCID: https://orcid.org/0000-0003-2274-0838)
- Yulan Wang (ORCID: https://orcid.org/0000-0002-2831-8737)
Institutions
- Department for Environment Food and Rural Affairs (GB)
- The University of Queensland (AU)
- Nanyang Technological University (SG)
- Imperial College London (GB)
Publication Details
- Journal
- Microbiome
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s40168-025-02049-2
- Citations
- 10
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 8.06
Funders
- Biotechnology and Biological Sciences Research Council