Molecular investigation of coronaviruses in Hungarian bats

Discussion:The genotypes identified in this study are known to be endemic for Russia and former Soviet Union countries: "Russian successful Beijing B0/W148 strain", LAM SIT254 that is widespread across all Russia, and Ural SIT262 that is epidemic MDR strain in Eastern Europe.On the other hand, some MDR subtypes are endemic for Siberia and Asian Russia, as a whole, such as hypervirulent Beijing 14717-15-cluster; low-virulent Beijing 1071-32 although the latter was already detected in southern and eastern Europe. Conclusion:Beijing genotype strains are highly prevalent (86.8%) in DR M. tuberculosis population in West Siberia, Russia.Among Beijing B0/W148 strains, 43.9% were pre-XDR.Thus, increasing proportion of primary MDR-TB in Siberia, Russia, is due to active transmission of Beijing strains, mostly MDR B0/W148 strains.