Rest and rinse: sleeping rhythms drive brain detox
Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Recent mouse work by Hauglund et al. shows how oscillatory surges in norepinephrine (NE) during sleep drive vascular pulsation and cerebrospinal fluid (CSF) movement to cleanse the brain.
Authors
- Leon Smyth (ORCID: https://orcid.org/0000-0001-9861-3574)
- Benjamin A. Plog (ORCID: https://orcid.org/0009-0000-9829-3670)
- Jonathan Kipnis (ORCID: https://orcid.org/0000-0002-3714-517X)
Institutions
- Washington University in St. Louis (US)
Publication Details
- Journal
- Trends in Immunology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1016/j.it.2025.02.007
- Citations
- 2
- Primary Topic
- Neuroscience of respiration and sleep
- Type
- article
- Field-Weighted Citation Impact
- 1.83
Funders
- Washington University in St. Louis
- Cure Alzheimer's Fund