Lack of neuropsychological effects following short-term subcallosal cingulate gyrus deep brain stimulation in treatment-resistant depression: a randomised crossover study
While no cognitive deterioration was observed following SCG-DBS, significant improvements in cognitive function were not evident. There may be a transient enhancement in processing speed; however, this effect is not fully understood. Future studies should include larger cohorts and extended stimulation periods to explore the long-term effects of SCG-DBS in TRD and the sustainability of improvements in cognitive domains.
Authors
- Yuelee Khoo (ORCID: https://orcid.org/0000-0002-7198-7207)
- Fatemeh Gholamali Nezhad
- Reinhard Janssen‐Aguilar (ORCID: https://orcid.org/0000-0001-5340-9078)
- Wendy Lou (ORCID: https://orcid.org/0000-0001-5590-8719)
- Amanda K. Ceniti (ORCID: https://orcid.org/0000-0002-5266-2212)
- Sidney H. Kennedy (ORCID: https://orcid.org/0000-0001-5339-7185)
- Sakina J. Rizvi
- Venkat Bhat (ORCID: https://orcid.org/0000-0002-8768-1173)
- Mary Pat McAndrews (ORCID: https://orcid.org/0000-0002-2287-5145)
- Andrés M. Lozano (ORCID: https://orcid.org/0000-0001-8257-3694)
- Vanessa K. Tassone (ORCID: https://orcid.org/0000-0002-9208-8809)
- Ilya Demchenko (ORCID: https://orcid.org/0000-0001-7876-4981)
- Peter Giacobbe (ORCID: https://orcid.org/0000-0001-6642-6221)
- Michelle Wu (ORCID: https://orcid.org/0009-0003-5458-7804)
- Qiaowei Lin
Institutions
- St. Michael's Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- University of Toronto (CA)
- Health Sciences Centre (CA)
- St Michael’s Hospital (IE)
- Public Health Ontario (CA)
- Krembil Foundation (CA)
- Krembil Research Institute
Publication Details
- Journal
- BMJ Mental Health
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/bmjment-2024-301408
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Foundation for Suicide Prevention
- Pfizer
- Fondation Brain Canada
- Sunovion
- Weston Brain Institute
- Royal College of Physicians and Surgeons of Canada
- Government of Canada
- Associated Medical Services
- University of Toronto
- Eisai
- Servier
- H. Lundbeck A/S
- Ministère de la Défense Nationale
- Allergan
- Canadian Institutes of Health Research