Frizzled-7-targeting antibody-derived bifunctional protein retargets NK cells against triple-negative breast cancer cells via MICA-NKG2D axis
SHH002-hu1-MICA maintains the targeting property of SHH002-hu1, successfully activates and retargets NK cells against TNBCs, especially TNBCSCs, exhibiting superior antitumor activities than SHH002-hu1. SHH002-hu1-MICA represents a promising new engager for NK cell-based immunotherapy for TNBC.
Authors
- Haiyan Xie (ORCID: https://orcid.org/0000-0002-1571-110X)
- Chenyue Wang
- Hao Yang (ORCID: https://orcid.org/0000-0002-3781-7271)
- Shuyang Mao
- Qingqing Huang (ORCID: https://orcid.org/0000-0002-5268-2256)
- Lisha Wu (ORCID: https://orcid.org/0000-0003-2847-1982)
- Xiaofei Zhang (ORCID: https://orcid.org/0000-0002-2564-9258)
- Duojie Li
- Jin Wang (ORCID: https://orcid.org/0000-0001-5420-5704)
- Tong Wang (ORCID: https://orcid.org/0000-0002-5980-3380)
- Xingxing Li (ORCID: https://orcid.org/0000-0002-7725-0329)
- Jing Xu (ORCID: https://orcid.org/0000-0002-8050-6831)
- Gang Huang (ORCID: https://orcid.org/0000-0003-1939-3978)
- Yang Lin (ORCID: https://orcid.org/0000-0001-8066-7435)
- Wei Xie (ORCID: https://orcid.org/0000-0001-6288-3046)
- Yuxia Liu (ORCID: https://orcid.org/0000-0003-1736-9253)
- Zitong Wang
Institutions
- Tulane University (US)
- Jiading District Central Hospital (CN)
- Shanghai Institute of Applied Physics (CN)
- Shanghai University of Medicine and Health Sciences (CN)
- Shanghai First Maternity and Infant Hospital (CN)
- Shanghai Cell Therapy Research Institute (CN)
- Rowan University (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/jitc-2024-009621
- Citations
- 6
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 4.78
Funders
- Natural Science Foundation of Shanghai
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China