Decoding chromosomal instability insights in CRC by integrating omics and patient-derived organoids
We first demonstrated that PDO models are a faithful reflection of CIN tissues at the genetic and phenotypic level. Our new findings prioritize a subset of genes and molecular processes putatively required to cope with the burden on cellular fitness imposed by CIN and associated with disease aggressiveness.
Authors
- Manuel Cabeza-Segura (ORCID: https://orcid.org/0000-0002-3257-1292)
- P. Rentero-Garrido
- Blanca García-Micó (ORCID: https://orcid.org/0000-0002-9370-7966)
- S. Zúñiga (ORCID: https://orcid.org/0000-0002-3272-7605)
- Juan Antonio Carbonell‐Asins (ORCID: https://orcid.org/0000-0002-8449-5674)
- Josefa Castillo (ORCID: https://orcid.org/0000-0002-4092-0085)
- Manuel M. Sánchez del Pino (ORCID: https://orcid.org/0000-0001-9696-7600)
- Valentina Gambardella (ORCID: https://orcid.org/0000-0001-6081-8830)
- Tania Fleitas (ORCID: https://orcid.org/0000-0002-2789-9082)
- Federica Papaccio (ORCID: https://orcid.org/0000-0002-0302-8696)
- Noelia Tarazona (ORCID: https://orcid.org/0000-0003-4888-1655)
- David Moro‐Valdezate (ORCID: https://orcid.org/0000-0003-0425-8677)
- Francisco Gimeno-Valiente (ORCID: https://orcid.org/0000-0003-0544-9459)
- Marisol Huerta (ORCID: https://orcid.org/0000-0002-8523-6711)
- M.F. Gutierrez-Bravo (ORCID: https://orcid.org/0000-0002-2730-2696)
- Carolina Martínez‐Ciarpaglini (ORCID: https://orcid.org/0000-0002-8797-2114)
- Andrés Cervantes (ORCID: https://orcid.org/0000-0003-3806-3691)
- Desamparados Roda
- Susana Roselló
Institutions
- University of Salerno (IT)
- Universitat de València (ES)
- Instituto de Salud Carlos III (ES)
- London Cancer (GB)
- Hospital Clínico Universitario de Valencia (ES)
- INCLIVA Health Research Institute (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- University College London (GB)
- Universidad Internacional SEK (EC)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s13046-025-03308-8
- Citations
- 7
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 10.30