Microtubule-modulating drugs alter sensitivity to isoflurane in mice
Microtubule-modulating drugs can affect not only sensitivity but also induction and emergence times to inhalational anesthetic isoflurane in mice. This study highlights a possible role of MTDs in modulating anesthetic effects in disparate directions, which has implications for anesthetic concentrations that should be used for induction, maintenance and emergence of anesthesia. These findings in rodents may have relevance to the perioperative care of cancer patients who receive MT-targeting chemotherapy drugs or even opioids for pain for prolonged periods.
Authors
- Zhongcong Xie (ORCID: https://orcid.org/0000-0002-0720-1759)
- Yuanlin Dong (ORCID: https://orcid.org/0000-0002-4760-0519)
- J. A. Jeevendra Martyn (ORCID: https://orcid.org/0000-0001-9618-4526)
- Jinsheng Yang (ORCID: https://orcid.org/0000-0002-1054-6344)
- Lucy Chen (ORCID: https://orcid.org/0000-0002-9956-8194)
- Weihua Ding (ORCID: https://orcid.org/0000-0001-8840-2917)
- Suyun Xia (ORCID: https://orcid.org/0000-0002-0395-5748)
- Jason T. Doheny
- Xue Zhou (ORCID: https://orcid.org/0000-0002-9365-5887)
- Jianren Mao (ORCID: https://orcid.org/0000-0003-0298-486X)
- Shiqian Shen (ORCID: https://orcid.org/0000-0003-0062-6831)
- Na Li (ORCID: https://orcid.org/0000-0002-9945-4189)
- Shiyu Wang (ORCID: https://orcid.org/0000-0001-8851-1697)
- Ge Li (ORCID: https://orcid.org/0000-0001-9030-884X)
- Xinbo Wu (ORCID: https://orcid.org/0000-0002-9846-2857)
- Yang Ren (ORCID: https://orcid.org/0000-0001-9195-8991)
- Zerong You
- Hyung Hwan Kim
Institutions
- Shriners Hospitals for Children - Erie (US)
- Massachusetts General Hospital (US)
- Center for Pain and the Brain (US)
Publication Details
- Journal
- BMC Anesthesiology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s12871-025-02956-9
- Citations
- 1
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- National Institutes of Health