Immune-related diagnostic indicators and targeted therapies for COPD combined with NASH were identified and verified via WGCNA and LASSO
The hub genes S100A9 and MYH2 in COPD and NASH were identified by various bioinformatics methods and a diagnostic model was constructed to improve the diagnostic efficiency. We also revealed some potential biological mechanisms of COPD and NASH and potential drugs for COPD-related NASH. Our findings provide potential new diagnostic and therapeutic options for COPD-associated NASH and may help reduce its prevalence.
Authors
- Haifeng Wu
- Lishuai Qu
- Zihan Xu (ORCID: https://orcid.org/0000-0001-5499-4803)
- Fengdan Xu (ORCID: https://orcid.org/0000-0002-6113-872X)
- Jinxia Liu (ORCID: https://orcid.org/0000-0001-8327-2228)
- Jianwei Hong
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1514422
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35