Design and Synthesis of Quaternized Antimicrobial Polymer against Escherichia coli

New strategies and approaches are required due to the rising levels of antibiotic resistance, which are frequently brought on by long-term misuse or overuse of conventional antimicrobial medications. Due to their minimal potential to produce drug-resistant bacteria, effective antimicrobial polymers have been garnering more attention. The incorporation of quaternary ammonium groups into polymers is among the most beneficial methods for fabricating biomaterials with antimicrobial properties. This study presents the synthesis pathway on developing quaternized jeffamine polymer (QJP) with efficient antimicrobial property. The QJP was prepared by post polymerization modification of Jeffamine ED2003 and the structural integrity of the QJP was investigated by NMR and thermal properties. The synthesized QJP exhibited activity against E. coli and kill time assay revealed the synthesized polymer has a bacteriostatic effect.