Synthesis, Moleculoar Docking and Antidiabetic Studies of Some 3,5-Disubstituted Thiazolidinediones

Novel thiazolidinedione derivatives incorporating a naphthylidene moiety were synthesized through Knoevenagel condensation reaction. The structural confirmation of the synthesized compounds was achieved through IR, mass and NMR spectral analyses. These compounds were assessed for their antidiabetic effects in alloxan-induced diabetic rats and in vivo antidiabetic analysis indicated that the compounds IIg and IIh exhibited significant antidiabetic activity. Molecular docking studies on the PPARγ receptor were performed to gain insights into the binding interactions of these designed compounds. The molecular docking studies identified compounds IIg and IIh as particularly effective against the PPARγ receptor. ADME properties were predicted using the QikProp module from the Schrödinger suite and all compounds complied with Lipinski’s rule of five, suggesting good oral absorption. Thus, compounds IIg and IIh may further be considered as potential antidiabetic agents.