Role and mechanism of Roux-en-Y gastric bypass in the treatment of diabetic urinary bladder hyperactivity by reducing TRPV1 and P2X3
RYGB downregulated the expression of TRPV1 by inhibiting inflammatory factors, thus inhibiting the enhancement of P2X3 by TRPV1. RYGB directly inhibited the activity of P2X3 by inhibiting ATP synthesis in the bladder epithelium to improve OAB.
Authors
- Qingjie Peng
- Mohanad Al-Qaisi
- Le-Yi Yu
- Jia-Jin Feng (ORCID: https://orcid.org/0000-0002-1023-8683)
- Rui He (ORCID: https://orcid.org/0000-0001-5288-9786)
- Bin-Cheng Huang
- Guangyong Li (ORCID: https://orcid.org/0000-0002-4999-5710)
- Xiaojiang Chen (ORCID: https://orcid.org/0000-0002-1180-6806)
- Qiangqiang Wang (ORCID: https://orcid.org/0000-0003-0576-4483)
- Shuai Ren (ORCID: https://orcid.org/0000-0002-4750-8317)
- Haifu Tian
- Cunling Ma
- Shuzhe Fan
Institutions
- Ningxia University (CN)
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- The Fourth People's Hospital of Ningxia Hui Autonomous Region (CN)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2025-02-28
- DOI
- https://doi.org/10.4239/wjd.v16.i4.96176
- Citations
- 1
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 1.84