Reno-protective impact of diosmin and perindopril in amikacin-induced nephrotoxicity rat model: modulation of SIRT1/p53/C-FOS, NF-κB-p65, and keap-1/Nrf2/HO-1 signaling pathways
The findings reveal the potential clinical application of combining Diosmin and perindopril to reduce AMC-induced nephrotoxicity, which requires further research in clinical settings.
Authors
- Nashwa Abdelaal (ORCID: https://orcid.org/0000-0002-5448-7403)
- Ahmed M. Atwa (ORCID: https://orcid.org/0000-0001-8580-4179)
- Yasmine H. Ahmed (ORCID: https://orcid.org/0000-0002-8061-6424)
- Dalia Zaafar (ORCID: https://orcid.org/0000-0002-7201-3658)
- Esraa A. Salem (ORCID: https://orcid.org/0009-0002-4191-9825)
- Marwa M. Khalaf
- Ehab A. M. El‐Shoura (ORCID: https://orcid.org/0000-0003-2448-7549)
- Ahmed A. N. Ahmed
- Basel A. Abdel-Wahab
- Ahmed Abomandour
Institutions
- Beni-Suef University (EG)
- The University of Texas MD Anderson Cancer Center (US)
- Cairo University (EG)
- Iraqi University (IQ)
- Al-Azhar University (ID)
- Najran University (SA)
- Menoufia University (EG)
- Egyptian Russian University (EG)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1080/08923973.2025.2469220
- Citations
- 3
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 4.67