Identification of glycolysis-related gene signatures for prognosis and therapeutic targeting in idiopathic pulmonary fibrosis
This study identifies GRGs as potential prognostic biomarkers for IPF and highlights their role in modulating immune responses within the fibrotic lung microenvironment. Notably, <i>AURKA, MERTK</i>, and <i>CXCR4</i> were associated with pathways linked to fibrosis progression and represent potential therapeutic targets. Our findings provide insights into metabolic reprogramming in IPF and suggest that targeting glycolysis-related pathways may offer novel pharmacological strategies for antifibrotic therapy.
Authors
- Zhenshun Cheng
- Menglin Zou (ORCID: https://orcid.org/0000-0001-5255-920X)
- Han Gao (ORCID: https://orcid.org/0000-0002-6021-2764)
- Zhongyi Sun
- Yuan Liu (ORCID: https://orcid.org/0000-0001-6227-024X)
- Minghui Zhu (ORCID: https://orcid.org/0009-0002-8020-4531)
- Weiwei Song (ORCID: https://orcid.org/0000-0002-0243-0050)
- Xingxing Hu (ORCID: https://orcid.org/0000-0003-4519-6644)
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Hainan General Hospital (CN)
- Wuhan Center for Disease Control and Prevention (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.3389/fphar.2025.1486357
- Citations
- 3
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56