Overview of distinct 8-oxoguanine profiles of messenger RNA in normal and senescent cancer cells
This study preliminarily revealed the different distribution patterns of o<sup>8</sup>G modification between normal CaCO<sub>2</sub> cells and senescent CaCO<sub>2</sub> cells. Our study established the link between o<sup>8</sup>G modification and cancer cell senescence, which provides a new insight into the mechanism of cancer cell senescence and a potential therapeutic target for subsequent cancer treatment.
Authors
- Jingwen Huang
- Linzhi Wei (ORCID: https://orcid.org/0000-0002-5066-6420)
- Yingying Zhao (ORCID: https://orcid.org/0000-0002-6170-6125)
- Yu Lin
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.3389/fcell.2025.1443888
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00