Asperosaponin VI suppresses ferroptosis in chondrocytes and ameliorates osteoarthritis by modulating the Nrf2/GPX4/HO-1 signaling pathway
Our findings suggest that AVI is a promising therapeutic agent for OA. It exerted its protective effect by regulating the Nrf2/GPX4/HO-1 signaling axis to inhibit cartilage cell ferroptosis and improve osteoarthritis.
Authors
- Zhimeng Zhang (ORCID: https://orcid.org/0000-0001-8952-2822)
- Wen‐Peng Xie (ORCID: https://orcid.org/0000-0002-3201-0858)
- Wenjie Chang
- Ximin Jin
- Daotong Yuan
- Yongkui Zhang (ORCID: https://orcid.org/0000-0001-8007-2706)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.3389/fphar.2025.1539092
- Citations
- 7
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 11.68
Funders
- National Natural Science Foundation of China
- Medical and Health Science and Technology Development Project of Shandong Province