Unveiling the immunological landscape of disseminated tuberculosis: a single-cell transcriptome perspective
These findings suggest that lymphopenia and T cell exhaustion, along with unique TCR signatures, may play critical roles in DTB pathogenesis. The reduced "CAAMD" motif and altered TCR clonotypes provide novel insights into the complex cellular dynamics associated with the disease, potentially offering new avenues for targeted immunological interventions.
Authors
- Jianping Xie (ORCID: https://orcid.org/0000-0002-8946-5597)
- Ying Zhao (ORCID: https://orcid.org/0009-0007-7886-5214)
- Fan Lin (ORCID: https://orcid.org/0000-0003-3810-6794)
- Yanhong Yu
- Chang Liu (ORCID: https://orcid.org/0000-0001-8489-2605)
- Qiao Zhang (ORCID: https://orcid.org/0009-0006-6348-2184)
- Yu Chen (ORCID: https://orcid.org/0000-0001-8484-040X)
- Zhou Liu (ORCID: https://orcid.org/0009-0008-1471-4369)
- Guirong Wang (ORCID: https://orcid.org/0000-0002-3794-0106)
- Lichao Fan (ORCID: https://orcid.org/0000-0002-3981-6731)
- Rui Hou (ORCID: https://orcid.org/0000-0002-6950-2290)
- Hongxiang Xu (ORCID: https://orcid.org/0000-0003-1388-5218)
- Zhen Gong (ORCID: https://orcid.org/0000-0001-8141-1087)
- Qiang Zhou (ORCID: https://orcid.org/0000-0001-5984-3705)
- Huasheng Xiao
- Zilu Wang (ORCID: https://orcid.org/0009-0004-0144-6888)
Institutions
- Tongji University (CN)
- Southwest University (CN)
- Capital Medical University (CN)
- Anhui Medical University (CN)
- Beijing Chest Hospital (CN)
- Shanghai Pulmonary Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Shanghai Clinical Research Center (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1527592
- Citations
- 4
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 5.58