Reduced plasma levels of GM-CSF is a common feature of Schistosoma mansoni-infected school-aged children
Our findings highlight the potential of using plasma GM-CSF levels to biomark <i>S. mansoni</i> infection and improve the sensitivity of single Kato-Katz based diagnostic for low- to-moderate burden infections.
Authors
- Séverin Donald Kamdem (ORCID: https://orcid.org/0000-0003-0183-8078)
- Leonel Meyo Kamguia
- Frank Brombacher (ORCID: https://orcid.org/0000-0001-8881-6781)
- Bernard Marie Zambo Bitye
- Katie Lennard (ORCID: https://orcid.org/0000-0002-7801-1063)
- Alim Oumarou
- Claudia Demarta‐Gatsi (ORCID: https://orcid.org/0000-0002-9610-2962)
- Thomas Spangenberg (ORCID: https://orcid.org/0000-0002-5654-8919)
- Justin Komguep Nono (ORCID: https://orcid.org/0000-0001-6153-9729)
Institutions
- South African Medical Research Council (ZA)
- University of Cape Town (ZA)
- Merck KGaA, Darmstadt (Germany) (DE)
- University of Utah (US)
- International Centre for Genetic Engineering and Biotechnology (ZA)
- Université des Sciences et Techniques de Masuku (GA)
- Ministry of Scientific Research and Innovation (CM)
- Ministry of Public Health (CM)
- Université Protestante d'Afrique Centrale (CM)
- Wellcome Centre for Infectious Diseases Research in Africa (ZA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1474575
- Citations
- 2
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 4.10
Funders
- International Center for Genetic Engineering and Biotechnology
- Merck KGaA
- Royal Society of Tropical Medicine and Hygiene
- Office of the Royal Society
- European and Developing Countries Clinical Trials Partnership