Inhibiting melanoma tumor growth: the role of oxidative stress-associated LINC02132 and COPDA1 long non-coding RNAs
Our findings suggest that upregulation of the <i>LINC02132</i> or <i>COPDA1</i> genes elevates intracellular reactive oxygen species (ROS) levels in melanoma cells, suppresses tumor cell proliferation, migration, and invasion, and promotes apoptosis. These results suggest a novel therapeutic strategy for melanoma treatment.
Authors
- Ruiqun Qi (ORCID: https://orcid.org/0000-0002-5856-4584)
- Zhigang Li (ORCID: https://orcid.org/0000-0001-5086-5334)
- Xiang Han (ORCID: https://orcid.org/0000-0003-1526-8264)
- Jingwen Xu (ORCID: https://orcid.org/0000-0002-2451-8037)
- Zhenzhen Mu (ORCID: https://orcid.org/0009-0009-2487-8102)
- Mingzhu Jin (ORCID: https://orcid.org/0000-0002-6543-194X)
- Hao Jiang (ORCID: https://orcid.org/0009-0001-3196-545X)
Institutions
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1558292
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.81