Dysregulated biosynthesis and hydrolysis of cyclic-di-adenosine monophosphate impedes sporulation and butanol and acetone production in Clostridium beijerinckii NCIMB 8052
Collectively, the results show that dysregulated production and hydrolysis of c-di-AMP severely impair butanol and acetone biosynthesis in <i>C. beijerinckii</i>, suggesting broader roles of this second messenger in the regulation of solventogenesis and likely, sporulation in this organism.
Authors
- Eric Agyeman-Duah
- Hoang Nam Truong (ORCID: https://orcid.org/0009-0002-7048-949X)
- Santosh Kumar (ORCID: https://orcid.org/0000-0003-4413-2841)
- Victor Ujor (ORCID: https://orcid.org/0000-0002-5518-6530)
- Marian M. Awaga-Cromwell
- Christopher Chukwudi Okonkwo
Institutions
- Northeastern University (US)
- University of Wisconsin–Madison (US)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.3389/fbioe.2025.1547226
- Citations
- 2
- Primary Topic
- Biofuel production and bioconversion
- Type
- article
- Field-Weighted Citation Impact
- 1.35