Suppression of NLRP3 inflammasome by a small molecule targeting CK1α–β-catenin–NF-κB and CK1α–NRF2–mitochondrial OXPHOS pathways during mycobacterial infection
This study reveals a previously unreported mechanism that pyrvinium can inhibit NLRP3 inflammasome and GSDMD-IL-1β inflammatory pyroptosis via targeting suppressing CK1α-β-catenin-NF-κB and CK1α-NRF2-mitochondrial OXPHOS pathways, suggesting that pyrvinium pamoate holds great promise as a host directed therapy (HDT) drug for mycobacterial-induced excessive inflammatory response.
Authors
- Qing Guan (ORCID: https://orcid.org/0000-0003-4687-4275)
- Qi Nie (ORCID: https://orcid.org/0000-0002-3191-9285)
- Xiao‐Lian Zhang (ORCID: https://orcid.org/0000-0002-8283-9381)
- Sheng Hong Liu (ORCID: https://orcid.org/0000-0001-5933-1101)
- Huan Xiong (ORCID: https://orcid.org/0000-0001-5106-167X)
- Yan Xie (ORCID: https://orcid.org/0000-0001-9743-6270)
- Xiangyu Song
- Yan Guang
Institutions
- Sun Yat-sen University (CN)
- Jinyintan Hospital (CN)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Wuhan University of Science and Technology (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1553093
- Citations
- 3
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.42