Amygdala Hyperactivity in Posttraumatic Stress Disorder: Disentangling Predisposing From Consequential Factors Using a Prospective Longitudinal Design
This prospective longitudinal study shows a predictive role for dorsal amygdala responsivity during threat anticipation for the development of trauma symptoms, while lateral amygdala responding to aversive events after trauma may reflect a failure to regulate. Our findings not only inform neurobiological theories of PTSD risk and vulnerability but also provide a starting point for prediction and intervention studies.
Authors
- Lycia D. de Voogd (ORCID: https://orcid.org/0000-0001-5927-6819)
- Vanessa A. van Ast (ORCID: https://orcid.org/0000-0003-2077-2799)
- Saskia B.J. Koch (ORCID: https://orcid.org/0000-0002-3628-6712)
- Floris Klumpers (ORCID: https://orcid.org/0000-0002-0631-5789)
- Reinoud Kaldewaij (ORCID: https://orcid.org/0000-0003-2177-7380)
- Mahur M. Hashemi (ORCID: https://orcid.org/0000-0002-0706-2816)
- Karin Roelofs (ORCID: https://orcid.org/0000-0002-8863-8978)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-8422-4014)
Institutions
- Linköping University (SE)
- Leiden University (NL)
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Mallinckrodt (United States) (US)
- Radboud Institute for Molecular Life Sciences (NL)
- Amsterdam University of Applied Sciences (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1016/j.biopsych.2025.02.894
- Citations
- 6
- Primary Topic
- Migration, Health and Trauma
- Type
- article
- Field-Weighted Citation Impact
- 13.84
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- European Research Council