A Unique Strategies for Psoriasis Management: Utilizing Nanoemulsion Based Insitu-Gel Formulation for Topical Administration of Mometasone Furoate

Mometasone furoate (MF) exhibits low oral bioavailability and can lead to significant adverse effects, renderingoral administration impractical. In order to enhance its solubility and permeability, a nanoemulsion-based in-situ gelwas developed for psoriasis treatment. Clove oil, Tween-80 (surfactant), and PEG 400 (co-surfactant) were chosenbased on their solubility profiles for MF. A pseudo-tertiary phase diagram was constructed to determine the optimalnanoemulsion formulation. The MF nanoemulsion (MF-NE) was prepared using a drop-by-drop aqueous titrationmethod. The optimized MF-NE demonstrated and thermodynamic stability and was characterized for globule size,zeta potential, refractive index, and viscosity. The final nanoemulsion formulation comprised 2% w/w oil and 18%w/w Smix (surfactant and co-surfactant mixture in 2:1 ratio). This nanoemulsion was incorporated into variousconcentrations of the gel poloxamer 407.