T cell receptor usage and epitope specificity amongst CD8+ and CD4+ SARS-CoV-2-specific T cells
This study highlights epitope-specificity heterogeneity, with some immunodominant responses, and suggests a potential role for long-lived SARS-CoV-2-specific T cell immunity. Shared TCR repertoires offers insights into cross-reactive and protective T cell clones, providing valuable information for optimizing vaccine strategies against emerging SARS-CoV-2 variants. The findings underscore the critical role of cellular immunity in long-term protection against SARS-CoV-2 and emphasizes the importance of understanding T cell dynamics.
Authors
- Nina Weis (ORCID: https://orcid.org/0000-0002-3133-2724)
- Thomas Blicher
- Ulrik Fahnøe (ORCID: https://orcid.org/0000-0002-2527-5751)
- Kivin Jacobsen
- Jens Bukh (ORCID: https://orcid.org/0000-0002-7815-4806)
- Alexander P. Underwood (ORCID: https://orcid.org/0000-0001-7971-6906)
- Amir H. Ameri (ORCID: https://orcid.org/0000-0003-0284-8286)
- Shan Feng (ORCID: https://orcid.org/0000-0003-2390-5454)
- Christina Sølund (ORCID: https://orcid.org/0000-0001-8149-3780)
- Brad R. Rosenberg (ORCID: https://orcid.org/0000-0002-5885-1276)
- Liselotte Brix
Institutions
- University of Copenhagen (DK)
- Copenhagen University Hospital (DK)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1510436
- Citations
- 3
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 4.19