An in vitro model demonstrating homeostatic interactions between reconstructed human gingiva and a saliva-derived multispecies biofilm
This model mimicked homeostatic HMI where a healthy gingiva supported a viable, diverse, and stable microbial community, incorporating bacterial genera found on native gingiva. The gingiva model maintained its tissue integrity and exerted protective responses in the presence of biofilms over time. This study adds to the evidence that shows the important role of the host in maintaining homeostatic HMI that are essential for oral health. Video Abstract.
Authors
- Sanne Roffel
- Aline Métris (ORCID: https://orcid.org/0000-0002-9725-5178)
- Mark J. Buijs (ORCID: https://orcid.org/0000-0002-4972-9797)
- Susan Gibbs (ORCID: https://orcid.org/0000-0002-3446-6138)
- Dongmei Deng (ORCID: https://orcid.org/0000-0003-3706-1678)
- Bastiaan P. Krom (ORCID: https://orcid.org/0000-0002-1497-1161)
- Vera Slomka (ORCID: https://orcid.org/0000-0002-4136-9627)
- Bernd W. Brandt (ORCID: https://orcid.org/0000-0002-1155-1989)
- Lin Shang (ORCID: https://orcid.org/0000-0002-9677-1074)
- Eleanor M. D’Agostino
Institutions
- Unilever (United Kingdom) (GB)
- Academic Center for Dentistry Amsterdam (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Institute of Infection and Immunity (CA)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Microbiome
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s40168-025-02033-w
- Citations
- 1
- Primary Topic
- Periodontal Regeneration and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.84
Funders
- National Ethnic Affairs Commission of the People's Republic of China