CALD1 inhibits invasion of human ovarian cancer cells by affecting cytoskeletal structure and the number of focal adhesion
Attenuated expression of <i>CALD1</i> in SK-OV-3 cells leads to fewer F-actin stress fibers, reducing the association between the cytoskeleton and Vinculin. This results in reduced cellular focal adhesions and increased invasiveness of SK-OV-3 cells, promoting OV cell metastasis. These findings suggest that <i>CALD1</i> may have important clinical implications in the diagnosis and treatment of OV.
Authors
- Zhenhui Wu
- Hongyu Guan (ORCID: https://orcid.org/0000-0002-1818-5467)
- Zhao Yang (ORCID: https://orcid.org/0000-0003-2856-7167)
- Shuwei Li (ORCID: https://orcid.org/0000-0002-4160-9133)
- Menglong Xu (ORCID: https://orcid.org/0000-0002-0087-5646)
- Yongchao Li (ORCID: https://orcid.org/0000-0003-2016-1824)
Institutions
- Beijing University of Chemical Technology (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.21037/tcr-24-1375
- Citations
- 1
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.94