To evaluate safety of the adsorption hemofiltration technique for treatment of septic shock in severe burn patients

Objectives: Evaluating the safety of continuous hemofiltration using an adsorbent membrane to treat septic shock in severe burns patients. Subjects and methods: The study describes 55 episodes of septic shock in 38 severe burn patients (16 - 60 years old) treated at the Intensive Care Unit, Le Huu Trac National Burn Hospital from January 2023 to June 2024. Results: The total number of filters used was 247, of which 8 filters had frozen membranes (3.2%), the average life of the filter was 15.87 hours. There were no cases of systolic blood pressure falling below 90 mmHg when entering the filter. During continuous veno-venous hemodiafiltration (CVVHDF): Body temperature was always within allowable limits; there were no differences in blood potassium levels, blood protein and albumin concentration, and hypocoagulation disorders at all time points (p > 0.05); blood sodium concentration decreased significantly to normal limits (p < 0.01). There was no difference in hypocoagulation status between time points (p > 0.05). There was 1 case of bleeding at the dialysis catheter fixation site (1.82%) and 2 cases of bleeding at the skin graft lesion requiring hemostatic treatment (3.62%). Conclusion: There were no differences in blood potassium levels, blood protein and albumin concentration, and hypocoagulation disorders at all time points.