Circulating white blood cell traits, chemokines and small cell lung cancer risk: a Mendelian randomization study
Using two-sample MR, we found that genetic predisposition to CD45RA<sup>+</sup> CD8<sup>+</sup> T cell, CD39<sup>+</sup> CD4<sup>+</sup> T cell, CXCL16 was associated with an increased risk of SCLC. There were suggestive inverse associations of genetically predicted dendritic cell, CD14<sup>-</sup> CD16<sup>+</sup> monocyte, PSGL-1 and CCL3 with SCLC risk. MVMR further confirmed that CXCL16 exerted a direct effect on SCLC, while CD14<sup>-</sup> CD16<sup>+</sup> monocyte and PSGL-1 indicated that they are protective in SCLC.
Authors
- Teng Ma (ORCID: https://orcid.org/0000-0003-1512-8018)
- Chenyang Wang (ORCID: https://orcid.org/0000-0003-2931-4743)
- Huizhong Zhu
Institutions
- Capital Medical University (CN)
- Beijing Chest Hospital (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.21037/tcr-24-1211
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00