Low expression of PRTN3 regulates the progression of gastric cancer by inhibition of cell cycle and promotion of apoptosis
Our study found that high expression of PRTN3 is associated with GC tumor N staging. And PRTN3 silencing could regulate GC progression by inhibiting the cell cycle and promoting apoptosis in GC cells, which could be a potential target for GC diagnosis and treatment.
Authors
- Xinran Lu (ORCID: https://orcid.org/0000-0001-5648-820X)
- Silvio Matsas
- Shichun Feng (ORCID: https://orcid.org/0000-0002-0008-5193)
- Hao Wu (ORCID: https://orcid.org/0000-0001-9552-3178)
- Renata D’Alpino Peixoto (ORCID: https://orcid.org/0000-0003-0053-7951)
- Marcelo Porfírio Sunagua Aruquipa (ORCID: https://orcid.org/0009-0009-0207-0022)
- Wang Fei (ORCID: https://orcid.org/0000-0003-1545-6919)
- Chao Shi (ORCID: https://orcid.org/0000-0002-3808-8699)
- Chong Tang (ORCID: https://orcid.org/0009-0000-6399-1057)
- Haibin Zhu (ORCID: https://orcid.org/0000-0001-6064-5407)
Institutions
- BC Cancer Agency (CA)
- Sociedade Brasileira de Oncologia Clínica (BR)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.21037/tcr-2025-153
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81