OPN3 enhances the proliferation, migration, and invasion of triple-negative breast cancer cells via the regulation of the TGF-β signaling pathway
The findings revealed that <i>OPN3</i> is involved in the stimulation of the TGF-β/SMAD2 signaling pathway, which promotes the growth, migration, and dissemination of TNBC cells. Moreover, <i>OPN3</i> can serve as a diagnostic biomarker and a treatment target for TNBC.
Authors
- Ke Tang
- Xiao Wu (ORCID: https://orcid.org/0000-0002-4884-657X)
- Jingjing Zhang (ORCID: https://orcid.org/0000-0002-0169-7124)
- Yumei Li (ORCID: https://orcid.org/0000-0002-2733-6159)
- Zhengquan Han
- Yameng Liu (ORCID: https://orcid.org/0000-0002-8661-6740)
- Yue Zhao (ORCID: https://orcid.org/0000-0001-5694-7904)
Institutions
- Bengbu Medical College (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.21037/tcr-24-1374
- Citations
- 1
- Primary Topic
- Caveolin-1 and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 1.15