Inhibition of liver cancer cell growth by metabolites S-adenosylmethionine and nicotinic acid originating from liver progenitor cells
This study has uncovered that HepLPCs have a suppressive influence on the proliferation of HCC cells. This is achieved through the impairment of mitochondrial function and the inhibition of key signaling pathways, namely, Notch1 and JAK1/STAT3, which are critical drivers of cancer progression. The secretion of the metabolites SAM and NA by HepLPCs appears to be instrumental in mediating these effects. These findings provide a solid foundation for identifying new therapeutic targets and clarifying the mechanisms through which HepLPCs can be harnessed to effectively treat HCC.
Authors
- Hong-Qian Ma
- Weijian Huang (ORCID: https://orcid.org/0000-0003-2958-134X)
- Xiao-Shu Qi
- Weifeng Yu (ORCID: https://orcid.org/0000-0003-1979-6304)
- He‐Xin Yan (ORCID: https://orcid.org/0000-0001-8390-650X)
- Yingfu Jiao (ORCID: https://orcid.org/0000-0002-4548-1819)
- Xu Zhou (ORCID: https://orcid.org/0000-0002-2556-6479)
- Qiu-Qiu Zhang
- Dan Tang (ORCID: https://orcid.org/0000-0003-0364-2220)
- Cai–Yang Chen
- Zhiying He (ORCID: https://orcid.org/0000-0002-0087-2277)
- Yu-ling Wu
- Wenming Liu (ORCID: https://orcid.org/0000-0001-9675-3215)
- Hanyong Sun
- Hongping Wu
- Yuxin Zhang (ORCID: https://orcid.org/0000-0003-0794-7646)
Institutions
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shanghai East Hospital (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
Publication Details
- Journal
- Journal of Gastroenterology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1007/s00535-025-02226-y
- Citations
- 3
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China
- Key Technologies Research and Development Program