Antitumor activity of gamma-irradiated Rosa canina L. against lung carcinoma in rat model: a proposed mechanism
Overall, the findings of this study suggest that Rosa canina enhances the anticancer effects of cisplatin by inhibiting cancer cell proliferation while simultaneously inducing autophagy and apoptosis. Thus, Rosa can be used as adjuvant to cisplatin chemotherapy to overcome its limitations which may be considered a new approach during lung cancer treatment strategy.
Authors
- Eman Salah Eldin
- Fatma SM Moawed
- Mostafa A. Farrag (ORCID: https://orcid.org/0000-0001-5829-6260)
- Esraa S. A. Ahmed (ORCID: https://orcid.org/0000-0001-5358-4394)
- Omayma AR Abo-Zaid (ORCID: https://orcid.org/0000-0002-1752-6709)
Institutions
- Benha University (EG)
- Egyptian Atomic Energy Authority (EG)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s12906-025-04813-1
- Citations
- 2
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 1.61