LncRNA MALAT1/Calpain-1 Axis in ATO Induced hERG Channel Deficiency
This study demonstrated that ATO-induced enhancement of calpain-1 and reduction of hERG may be linked to the aberrant overexpression of lncRNA MALAT1. Tanshinone IIA and fexofenadine restored the hERG protein levels potentially by decreasing MALAT1 expression and counteracting ATO's effects on the MALAT1/calpain-1 pathway. Collectively, our research uncovers a previously unreported regulatory mechanism underlying ATO-induced acLQTS. Moreover, it identifies potential molecular targets and intervention strategies for acLQTS therapy.
Authors
- Yuexin Li (ORCID: https://orcid.org/0000-0001-8525-2853)
- Yuhao Zhang (ORCID: https://orcid.org/0000-0002-6801-9010)
- Yang Li (ORCID: https://orcid.org/0000-0002-0677-3245)
- Caichuan Yan (ORCID: https://orcid.org/0000-0001-8626-2236)
- Philip Q. Ding (ORCID: https://orcid.org/0000-0002-0413-5485)
- Xin Zhao (ORCID: https://orcid.org/0000-0002-5836-5585)
- Xiaoxu Li (ORCID: https://orcid.org/0000-0002-4700-3300)
- Baoxin Li (ORCID: https://orcid.org/0000-0002-1680-3970)
- Jinyang Sun
Institutions
- Harbin Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/dddt.s502776
- Citations
- 2
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China