Network Pharmacology and Experimental Verification: Phellodendri Chinensis Cortex-Cnidii Fructus Herb Pair Alleviates Atopic Dermatitis by Regulating the TLR4/NF-κB Pathway
The anti-AD effects of PC may be attributed to its modulation of the TLR4/NF-κB signaling pathway, reduction of NF-кB expression in the nucleusim, downregulation of inflammatory cytokine levels, provement of skin histopathological manifestations, and reduction of skin pruritus.
Authors
- Jiafeng Wang (ORCID: https://orcid.org/0000-0002-1753-6499)
- Xiaolong Jiang (ORCID: https://orcid.org/0000-0001-8066-1383)
- Pengze Li
- Zhaoshuang Zhan
- Peng Sun (ORCID: https://orcid.org/0000-0002-9508-2904)
- Xinyue Liu (ORCID: https://orcid.org/0000-0002-3479-4684)
- Zichen Xu (ORCID: https://orcid.org/0000-0002-6469-7869)
- Lele Chen (ORCID: https://orcid.org/0000-0002-6064-1569)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/dddt.s505248
- Citations
- 6
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 12.03