Club cell secretory protein 16 promotes cell proliferation and inhibits inflammation and pyroptosis in response to particulate matter 2.5-induced epithelial damage in asthmatic mice
CC16 efficiently remedies airway epithelial cells (AECs) harm caused by PM<sub>2.5</sub> in asthmatic mice, fostering cellular multiplication and suppressing pyroptosis and inflammation. Our findings imply CC16's potential as a promising therapeutic option for addressing future health threats stemming from PM<sub>2.5</sub> exposure.
Authors
- Xiaobing Zeng
- Jian‐Lin Wu (ORCID: https://orcid.org/0000-0002-3875-185X)
- Xiaolong Liu (ORCID: https://orcid.org/0000-0002-3096-4981)
- Xiaowen Chen (ORCID: https://orcid.org/0000-0002-3118-3837)
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
- Wenxue Hu (ORCID: https://orcid.org/0000-0003-4181-5719)
- Lei Jiang (ORCID: https://orcid.org/0000-0002-9509-370X)
- Shaohua Luo
- Jinle Lin
- Jing Zhang (ORCID: https://orcid.org/0009-0001-5370-0014)
- Fang Wang (ORCID: https://orcid.org/0000-0001-7729-5669)
Institutions
- Beijing Tsinghua Chang Gung Hospital (CN)
- Shenzhen Second People's Hospital (CN)
- South China University of Technology (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Journal of Thoracic Disease
- Published
- 2025-02-01
- DOI
- https://doi.org/10.21037/jtd-24-1371
- Citations
- 5
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.99