Migration of Regulatory T Cells to the Peritumor Microenvironment of Experimental Glioblastoma
The dynamics of GL-261 glioma microenvironment infiltration by Tregs has been investigated. The glioblastoma cells were shown to activate Tregs in the peritumor space <i>in vivo</i> and to promote their selective expansion when co-cultured with TILs <i>in vitro</i>. These data can be used for further studies on C57Bl/6-FoxP3-eGFP mice to find approaches to inactivate Tregs in glioblastoma.
Authors
- M V Shirmanova
- Daria A. Chudakova (ORCID: https://orcid.org/0000-0002-9354-6824)
- G M Yusubalieva
- Владимир П. Баклаушев (ORCID: https://orcid.org/0000-0003-1039-4245)
- Pavel Melnikov (ORCID: https://orcid.org/0000-0002-2544-878X)
- Elvira P. Yanysheva (ORCID: https://orcid.org/0009-0007-0032-3474)
Institutions
- Privolzhsky Research Medical University (RU)
- Federal Medical Research Centre for Psychiatry and Narcology (RU)
- Federal Medical-Biological Agency (RU)
Publication Details
- Journal
- Sovremennye tehnologii v medicine
- Published
- 2025-02-28
- DOI
- https://doi.org/10.17691/stm2025.17.1.07
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Russian Science Foundation