Developing a PK-PD model for propofol in exhaled air and the BIS following fospropofol disodium in beagles
This study is the first to develop a PK-PD model for exhaled propofol in beagles after fospropofol disodium administration. The PK profile was described by a two-compartment model with a first-order delay, and the PD profile was modeled using an inhibitory sigmoid E<sub>max</sub> model with an indirect connection model to capture the lag between BIS and exhaled propofol peaks.
Authors
- Yi Kang (ORCID: https://orcid.org/0000-0002-0166-0823)
- Zhongjun Zhao (ORCID: https://orcid.org/0000-0001-8346-0421)
- Wensheng Zhang (ORCID: https://orcid.org/0000-0002-2737-8623)
- Xiaoxiao Li (ORCID: https://orcid.org/0000-0001-8789-6169)
- Pan Chang
- Xing Liu (ORCID: https://orcid.org/0000-0003-2612-4821)
- Yixiang Duan
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s12917-025-04570-w
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sichuan Province Science and Technology Support Program