Auto-antibodies against interferons are common in people living with chronic hepatitis B virus infection and associate with PegIFNα non-response
HBV and PegIFNα individually may induce broad autoreactivity associated with dysregulated antiviral immune responses. Auto-Ab screening prior to PegIFNα treatment or other immunotherapies may play a critical role in predicting treatment responses.
Authors
- Patrick T.F. Kennedy (ORCID: https://orcid.org/0000-0001-9201-0094)
- Claudia Mauri (ORCID: https://orcid.org/0000-0001-9761-2625)
- Laura E. McCoy (ORCID: https://orcid.org/0000-0001-9503-7946)
- David Etoori (ORCID: https://orcid.org/0000-0002-2807-6272)
- Hannah F. Bradford (ORCID: https://orcid.org/0000-0002-6827-3190)
- Upkar S. Gill (ORCID: https://orcid.org/0000-0001-6146-9708)
- Sarah Griffith
- Douglas Fink (ORCID: https://orcid.org/0000-0003-4210-2411)
- Mala K. Maini (ORCID: https://orcid.org/0000-0001-6384-1462)
- Orest Idilli
- Nikita Kartikapallil
- Olivia Payne
- Robert Hill (ORCID: https://orcid.org/0000-0001-5125-3997)
Institutions
- Queen Mary University of London (GB)
- Royal Free London NHS Foundation Trust (GB)
- University College London (GB)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101382
- Citations
- 2
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- University College London
- Medical Research Foundation