Serum metabolomic profiling uncovered metabolic shifts in individuals upon moderate-altitude exposure and identified the potentiality of beta-alanine to ameliorate hyperuricemia
This study reveals serum urate and metabolome altered in moderate-altitude exposed individuals and Beta-Alanine intervention could ameliorate hyperuricemia. Our findings suggest that targeting the circulating metabolome may pave novel avenues to counter diseases associated with HU.
Authors
- Xuanfu Chen
- Yanqun Fan (ORCID: https://orcid.org/0000-0002-8698-464X)
- Long Peng (ORCID: https://orcid.org/0000-0001-9654-953X)
- Xin Li (ORCID: https://orcid.org/0000-0003-2867-9206)
- Haiwei He (ORCID: https://orcid.org/0000-0003-4395-9898)
- Jiahui Ma
- Feier Song (ORCID: https://orcid.org/0000-0003-0881-1249)
- Dingchen Wang (ORCID: https://orcid.org/0009-0008-1730-7363)
- Xin Qi (ORCID: https://orcid.org/0000-0002-6040-9567)
- J H Zhou (ORCID: https://orcid.org/0000-0002-8384-4174)
- Yimei Hong (ORCID: https://orcid.org/0000-0002-0736-4507)
- Zhipeng Liu (ORCID: https://orcid.org/0000-0002-0625-463X)
- Zhibo Yang (ORCID: https://orcid.org/0000-0001-6028-447X)
- Guoxiang Zou
- Yu-E Wang
Institutions
- Biocon (Switzerland) (CH)
- Ganzhou People's Hospital (CN)
- Beijing Biocytogen (China) (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Gaozhou People's Hospital (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.redox.2025.103546
- Citations
- 7
- Primary Topic
- High Altitude and Hypoxia
- Type
- article
- Field-Weighted Citation Impact
- 12.72