Long noncoding RNA hottip maintained skeletal homeostasis via suppressing the enhancer of zeste homolog 2 (Ezh2)/histone methylation regulatory axis
In summary, this study identifies Hottip as a critical regulator in osteoblast and osteoclast differentiation, crucial for maintaining skeletal homeostasis. Hottip emerges as a promising therapeutic target for enhancing bone regeneration. These findings contribute valuable insights into lncRNA-mediated mechanisms governing skeletal dynamics<b>.</b>
Authors
- Yongxin Mai (ORCID: https://orcid.org/0000-0001-5763-5857)
- Shuting Zhou
- Puping Liang (ORCID: https://orcid.org/0000-0003-3593-2599)
- Chuan-Jian Shi (ORCID: https://orcid.org/0000-0003-1509-3492)
- Weicheng Liang (ORCID: https://orcid.org/0000-0001-5425-5402)
- Jinfang Zhang (ORCID: https://orcid.org/0000-0002-4276-8291)
- Jiang Shao (ORCID: https://orcid.org/0000-0001-5307-7587)
- Zhipeng Li (ORCID: https://orcid.org/0000-0003-4217-3797)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Southern Medical University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Non-coding RNA Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.ncrna.2025.01.003
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China