Comparison of [18F]fluorodeoxyglucose and [68Ga]Gallium DOTA-TATE in patients with active giant cell arteritis
In this pilot study of patients with active GCA, the arterial uptake of [<sup>68</sup>Ga]Ga-HA-DOTA-TATE was lower and less conspicuous compared to [<sup>18</sup>F]FDG. While further evaluation in larger cohorts is needed, a clear advantage of [<sup>68</sup>Ga]Ga-HA-DOTA-TATE over [<sup>18</sup>F]FDG for detecting vascular inflammation in GCA was not identified. TRIAL REGISTRATION, CLINICALTRIALS.GOV: NCT03812302, registered 2019-01-18, URL: https://clinicaltrials.gov/search?cond=dotatate%20%26;term=giant%20cell%20arteritis .
Authors
- Jan Willem Cohen Tervaert (ORCID: https://orcid.org/0000-0001-7407-6364)
- Jan Andersson (ORCID: https://orcid.org/0000-0003-2593-884X)
- Elaine Yacyshyn (ORCID: https://orcid.org/0000-0002-2753-2790)
- Alison Clifford (ORCID: https://orcid.org/0000-0001-5974-1821)
- Ryan Hung (ORCID: https://orcid.org/0000-0001-5710-1476)
- Frank Wuest (ORCID: https://orcid.org/0000-0002-6705-6450)
- Jonathan Abele (ORCID: https://orcid.org/0000-0002-5311-1332)
- Susan Pike
- Paolo Raggi
- Eric Lenza
- Glen Jickling
Institutions
- Alberta Health Services (CA)
- University of Alberta (CA)
- Maastricht University (NL)
- Translational Research in Oncology (CA)
Publication Details
- Journal
- EJNMMI Reports
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s41824-025-00242-y
- Citations
- 3
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- University Hospital Foundation