Anti-miRNA therapeutics for uterine fibroids
Anti-miR-148a-3p LNA inhibits the proliferation of patient-derived leiomyoma cells and tumor growth in vivo, by suppressing miR-148a-3p levels and increasing TXNIP and Nrp1 gene expression. The highest therapeutic effect was observed with systemic administration, positioning miR-148a-3p inhibition as a promising therapeutic strategy for uterine leiomyoma in humans.
Authors
- Maurizio Pinamonti (ORCID: https://orcid.org/0000-0002-9277-9378)
- Chiara Agostinis (ORCID: https://orcid.org/0000-0002-8315-2258)
- Sharad Saxena (ORCID: https://orcid.org/0000-0002-9379-4940)
- Alberto Cook‐Calvete (ORCID: https://orcid.org/0000-0003-1770-2386)
- Maria Concetta Volpe (ORCID: https://orcid.org/0000-0002-7121-2874)
- Serena Zacchigna (ORCID: https://orcid.org/0000-0001-6705-3076)
- Roman Vuerich (ORCID: https://orcid.org/0000-0002-5519-248X)
- Giovanni Di Lorenzo (ORCID: https://orcid.org/0000-0002-8845-1206)
- Andrea Colliva (ORCID: https://orcid.org/0009-0001-4378-6248)
- Simone Vodret (ORCID: https://orcid.org/0000-0003-1627-4404)
- Luca Braga (ORCID: https://orcid.org/0000-0002-9827-6755)
- Giuseppe Ricci (ORCID: https://orcid.org/0000-0002-8031-1102)
- Gabriella Zito (ORCID: https://orcid.org/0000-0002-7836-4934)
- Nadja Ring (ORCID: https://orcid.org/0000-0001-6006-6544)
- Federico Romano (ORCID: https://orcid.org/0000-0003-2157-8330)
- Blendi Ura (ORCID: https://orcid.org/0000-0003-2669-439X)
- Roberta Bulla (ORCID: https://orcid.org/0000-0003-1737-5776)
Institutions
- University of Trieste (IT)
- IRCCS Materno Infantile Burlo Garofolo (IT)
- International Centre for Genetic Engineering and Biotechnology (IT)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1016/j.biopha.2025.117946
- Citations
- 4
- Primary Topic
- Uterine Myomas and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.23