Sex differences in reward-based operant conditioning performance and neurotransmitter changes following chronic sleep restriction stress in rats
CSR impairs cognitive function in both male and female rats, with significant sex differences observed. Male CSR rats exhibited impaired signal discrimination, while CSR impaired extinction learning in female rats. These impairments are accompanied by CSR-induced oxidative stress, neurotransmitter dysregulation, and disturbances in the tryptophan metabolic pathway. These findings underscore the importance of considering sex differences in understanding the effects of sleep deprivation on cognitive function and developing targeted intervention strategies.
Authors
- Muhan Yu
- Shanguang Chen (ORCID: https://orcid.org/0000-0002-7030-8196)
- M. Iqbal Choudhary (ORCID: https://orcid.org/0000-0001-5356-3585)
- Fang Chen (ORCID: https://orcid.org/0000-0003-4971-8729)
- Yiwen Zhang (ORCID: https://orcid.org/0000-0001-7894-9556)
- Yinghui Li (ORCID: https://orcid.org/0000-0002-9294-4652)
- Xinmin Liu (ORCID: https://orcid.org/0000-0001-6452-4645)
- Ning Jiang (ORCID: https://orcid.org/0000-0002-1534-0177)
Institutions
- Ningbo University (CN)
- University of Karachi (PK)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- International Center for Chemical and Biological Sciences (PK)
- Shinva (China) (CN)
- China Astronaut Research and Training Center (CN)
Publication Details
- Journal
- Behavioral and Brain Functions
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s12993-025-00268-z
- Citations
- 3
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 4.29