Pulmonary Hyalinizing Granuloma: A Rare and Challenging Case

Hyalinizing Pulmonary Granuloma (HPG) is a rare pseudoneoplastic pulmonary lesion requiring histopathological diagnosis, often challenging for pathologists. We present the case of a 54-year-old woman with an incidental HPG diagnosis. She had a history of urogenital tuberculosis but no prior pulmonary involvement. Macroscopic examination revealed a 35-mm firm nodular lesion, while histology showed eosinophilic, hyalinized lamellae concentrically arranged around blood vessels, interspersed with histiocytes, lymphocytes, and plasma cells. Congo red staining was negative. Pathologists should consider HPG when the morphology is suggestive. Diagnosis of HPG relies on collaboration between pathologists, surgeons, and radiologists.