Exploration of the plasma proteomic profile of patients at risk of thromboembolic events
Although VKA treatment-specific and disease-specific signatures were captured, our study highlights that the challenges of discovering biomarkers in patients at risk of thromboembolic events lie in the heterogeneity of individual plasma profiles in relation to treatment and etiology.
Authors
- Arie J. Hoogendijk (ORCID: https://orcid.org/0000-0002-3082-2289)
- Tom Van De Berg
- Jeroen Eikenboom (ORCID: https://orcid.org/0000-0002-3268-5759)
- Suzanne C. Cannegieter (ORCID: https://orcid.org/0000-0003-4707-2303)
- Carmen van der Zwaan
- Marieke J. H. A. Kruip (ORCID: https://orcid.org/0000-0002-0265-4871)
- Iris C. Kreft (ORCID: https://orcid.org/0000-0002-3595-992X)
- Hugo Ten Cate (ORCID: https://orcid.org/0000-0001-7796-4463)
- Bart J.M. van Vlijmen (ORCID: https://orcid.org/0000-0003-0208-6453)
- J. Burggraaf (ORCID: https://orcid.org/0000-0002-9904-7495)
- Maartje van den Biggelaar (ORCID: https://orcid.org/0000-0001-6970-5496)
- Bas C. T. van Bussel (ORCID: https://orcid.org/0000-0003-1621-7848)
- Frank van Rosmalen (ORCID: https://orcid.org/0000-0002-9522-3711)
- Eleonora Camilleri (ORCID: https://orcid.org/0000-0002-9502-2434)
- Nienke van Rein (ORCID: https://orcid.org/0000-0001-9201-401X)
- Anne‐Marije Hulshof (ORCID: https://orcid.org/0000-0001-9688-2324)
- Yvonne Henskens (ORCID: https://orcid.org/0000-0003-0217-6045)
- Jonathan M. Coutinho (ORCID: https://orcid.org/0000-0001-9941-4155)
- Eva R. Smit (ORCID: https://orcid.org/0009-0008-2001-1205)
Institutions
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- Erasmus MC (NL)
- Sanquin (NL)
- Maastricht University (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.rpth.2025.102713
- Citations
- 1
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Universiteit Leiden
- ZonMw
- Leids Universitair Medisch Centrum
- Nederlandse Vereniging voor Trombose en Hemostase
- Trombosestichting Nederland