Relationship of Acute Myocardial Infarction with Increased Uric Acid Levels

Objective: To determine the relationship between hyperuricemia and acute myocardial infarction and its correlation with gender, smoking, and diabetes mellitus in the context of acute myocardial infarction. Study Design: Cross-sectional analytical study Place and Duration of Study: Cardiology Department of Mardan Medical Complex, Pakistan from August to October 2023. Methodology: Inclusion of 307 patients suspected of acute myocardial infarction, with demographic data collected via a predesigned proforma and uric acid levels measured in the Hospital laboratory. Non-probability convenient sampling was utilized. Informed consent was obtained from all patients to ensure confidentiality and safety. Results: Of 307 patients, 214(69.7%) were males, and 93(30.3%) were females, with a mean age of 56.82±11.71 years. Hyperuricemia was observed in 160 patients (52.1%). Among 191 subjects (62.21%) diagnosed with MI, 142(74.34%) had hyperuricemia. Additionally, 116 patients (37.78%) presented with unstable angina or alternative diagnoses, with 18(15.51%) showing hyperuricemia. Statistical analysis revealed a significant association between hyperuricemia and acute MI (p<0.001) and diabetes mellitus (p=0.001). However, no significant relationship was found between hyperuricemia and sex, hypertension, or smoking. Conclusion: The study established a significant association between hyperuricemia and myocardial infarction, as well as diabetes mellitus. Despite a high prevalence of hypertensive patients, a significant association with hyperuricemia was not observed. These findings underscore the importance of considering hyperuricemia as a potential risk factor for acute myocardial infarction, particularly in individuals with concomitant diabetes mellitus.