Correlation of Serum Gamma Glutamyl Transferase and Prostate Specific Antigen Level in Patients with Prostate Disorders

Objective: To correlate gamma-glutamyl transferase, prostate-specific antigen, and prostate-specific antigen density with ultrasound findings, including prostate-specific antigen volume and density, in patients with prostate disorders and to compare differences between Gamma-GT, prostate-specific antigen levels, and density based upon “American Urological Association” score questionnaire groups. Study Design: Cross sectional study. Place and Duration of Study: Combined Military Hospital Multan, Pakistan, from Nov 2019 to Dec 2021. Methodology: We measured prostate indices, including prostate-specific antigen, prostate-specific antigen volume, prostate-specific antigen size, and prostate-specific antigen density, through biochemical measurements and ultrasound examination in a patient population [(n=336) and (age 45-90 years)] randomly after several exclusions that could have affected the results of gamma-glutamyl transferase in known prostate disorders. Results: Gamma-glutamyl Gamma-glutamyl indices showed a low correlation with prostate-specific antigen levels (p-value= 0.170), ultrasound measures of the prostate gland (p-value=0.088), and derived indices incorporating prostate-specific antigen results (p-value=0.025). PSA showed moderate to higher correlation with Alkaline phosphatase (r=0.422, p<0.001), gamma glutamyl transferase (r=0.170, p=<0.001), PSA volume (r=0.513, p=<0.001), prostate gland size (r=0.520, p=<0.001) and PSA density (r=0.754, p=<0.001). Statistical analysis for various biochemical parameters and PSA measures between groups formulated based on prostate size and the AUA score system was not statistically significant. Conclusion: Prostate derived ultrasound measures and PSA density showed a higher correlation with PSA. Gamma glutamyl transferase may not help depict prostate gland disease.