Phase II Trial of Atezolizumab and Bevacizumab for Treatment of HPV-Positive Unresectable or Metastatic Squamous Cell Carcinoma of the Anal Canal
Atezolizumab and bevacizumab demonstrate activity similar to anti-PD-1 antibodies alone for unresectable anal cancer. Our translational data identify undescribed chromosomal and transcriptomic biomarkers associated with survival for metastatic anal cancer. These correlative findings warrant confirmation and further validation in larger, prospective immunotherapy trials for advanced anal cancer.
Authors
- Armeen Mahvash (ORCID: https://orcid.org/0000-0003-0416-4566)
- Scott E. Woodman (ORCID: https://orcid.org/0000-0002-1157-6991)
- Cathy Eng (ORCID: https://orcid.org/0000-0003-2335-0612)
- Van Karlyle Morris (ORCID: https://orcid.org/0000-0002-4911-2252)
- Daniel M. Halperin (ORCID: https://orcid.org/0000-0002-3113-930X)
- Kangyu Lin (ORCID: https://orcid.org/0000-0003-0140-2557)
- Ignacio I. Wistuba (ORCID: https://orcid.org/0000-0003-3365-6340)
- Suyu Liu (ORCID: https://orcid.org/0000-0003-0126-2646)
- Edwin R. Parra (ORCID: https://orcid.org/0000-0001-9068-1636)
- James C. Yao (ORCID: https://orcid.org/0000-0002-1875-3962)
- Baohua Sun (ORCID: https://orcid.org/0000-0003-0393-8099)
- Haifeng Zhu (ORCID: https://orcid.org/0000-0001-7315-4105)
- Mark Knafl (ORCID: https://orcid.org/0000-0002-3953-2173)
- Priya Bhosale (ORCID: https://orcid.org/0000-0003-4014-4941)
- Arjun Peddireddy (ORCID: https://orcid.org/0009-0009-1442-7789)
- Julia Mendoza‐Pérez (ORCID: https://orcid.org/0000-0002-4019-0633)
- Seema Prasad
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Vanderbilt University (US)
- The University of Texas Health Science Center (US)
- Boehringer Ingelheim (United States) (US)
- Vanderbilt University Medical Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1512
- Citations
- 1
- Primary Topic
- Colorectal and Anal Carcinomas
- Type
- article
- Field-Weighted Citation Impact
- 2.01