Germline–Somatic Interactions in BRCA-Associated Cancers: Unique Molecular Profiles and Clinical Outcomes Linking <i>ATM</i> to <i>TP53</i> Synthetic Essentiality

gATM-associated cancers seem to require intact p53 activity and this synthetic essentiality may be used to guide targeted therapies that perturb canonical TP53 function.

Authors

Institutions

Publication Details

Journal
Clinical Cancer Research
Published
2025-02-28
DOI
https://doi.org/10.1158/1078-0432.ccr-24-2058
Citations
3
Primary Topic
Cancer Genomics and Diagnostics
Type
article
Field-Weighted Citation Impact
2.81
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Germline–Somatic Interactions in BRCA-Associated Cancers: Unique Molecular Profiles and Clinical Outcomes Linking ATM to TP53 Synthetic Essentiality

Fergus J. Couch, Stamatina Fragkogianni, Binyam Yilma, Justin M. Drake et al.
3 citations
Clinical Cancer Research
Cancer Genomics and Diagnostics
2.81
article

Germline–Somatic Interactions in BRCA-Associated Cancers: Unique Molecular Profiles and Clinical Outcomes Linking ATM to TP53 Synthetic Essentiality

Fergus J. Couch, Stamatina Fragkogianni, Binyam Yilma, Justin M. Drake, Calvin Chao, Ali T. Arafa, Ella Boytim, Catherine Handy Marshall, Ymke van der Pol, Emil Lou, Megan Ludwig, Hai Dang Nguyen, Christine Luo, William B. Isaacs, Scott M. Dehm, Weijie Zhang, Emily A. Teslow, Siddhartha Yadav, Elizabeth Mauer, R. Stephanie Huang, Deborah K. Armstrong, Samuel Kellen, Justin H. Hwang, Minxuan Huang, Arockia Jayaraj, Emmanuel S. Antonarakis
article en
3 citations

Abstract

gATM-associated cancers seem to require intact p53 activity and this synthetic essentiality may be used to guide targeted therapies that perturb canonical TP53 function.

Clinical Cancer ResearchVol. 31(9)
University of Minnesota (US), Mayo Clinic (US), Johns Hopkins University (US), Johns Hopkins Medicine (US), University of Minnesota System (US), Sidney Kimmel Cancer Center (US), Tempus Labs (United States) (US), Mayo Clinic in Arizona (US), Mayo Clinic in Florida (US)
Good health and well-being
Openalex Percentile: Top 11%
Cancer Genomics and Diagnostics
2.81
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.