Germline–Somatic Interactions in BRCA-Associated Cancers: Unique Molecular Profiles and Clinical Outcomes Linking <i>ATM</i> to <i>TP53</i> Synthetic Essentiality
gATM-associated cancers seem to require intact p53 activity and this synthetic essentiality may be used to guide targeted therapies that perturb canonical TP53 function.
Authors
- Fergus J. Couch (ORCID: https://orcid.org/0000-0001-9417-9985)
- Stamatina Fragkogianni (ORCID: https://orcid.org/0000-0002-5960-8921)
- Binyam Yilma (ORCID: https://orcid.org/0009-0007-8845-5390)
- Justin M. Drake (ORCID: https://orcid.org/0000-0002-8329-7748)
- Calvin Chao (ORCID: https://orcid.org/0000-0002-9704-9227)
- Ali T. Arafa
- Ella Boytim (ORCID: https://orcid.org/0009-0007-8062-6431)
- Catherine Handy Marshall (ORCID: https://orcid.org/0000-0002-2653-4110)
- Ymke van der Pol (ORCID: https://orcid.org/0000-0002-3040-5848)
- Emil Lou (ORCID: https://orcid.org/0000-0002-1607-1386)
- Megan Ludwig (ORCID: https://orcid.org/0000-0003-3133-3679)
- Hai Dang Nguyen (ORCID: https://orcid.org/0000-0002-4200-8778)
- Christine Luo
- William B. Isaacs (ORCID: https://orcid.org/0000-0001-6599-6775)
- Scott M. Dehm (ORCID: https://orcid.org/0000-0002-7827-5579)
- Weijie Zhang (ORCID: https://orcid.org/0000-0002-8978-8310)
- Emily A. Teslow (ORCID: https://orcid.org/0000-0001-5506-1749)
- Siddhartha Yadav (ORCID: https://orcid.org/0000-0003-4630-9903)
- Elizabeth Mauer (ORCID: https://orcid.org/0009-0001-8033-0696)
- R. Stephanie Huang (ORCID: https://orcid.org/0000-0002-9862-0368)
- Deborah K. Armstrong (ORCID: https://orcid.org/0000-0003-0852-803X)
- Samuel Kellen
- Justin H. Hwang (ORCID: https://orcid.org/0000-0003-1686-7103)
- Minxuan Huang
- Arockia Jayaraj
- Emmanuel S. Antonarakis (ORCID: https://orcid.org/0000-0003-0031-9655)
Institutions
- University of Minnesota (US)
- Mayo Clinic (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- University of Minnesota System (US)
- Sidney Kimmel Cancer Center (US)
- Tempus Labs (United States) (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2058
- Citations
- 3
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 2.81