Inhalation dosimetry and dose-response analysis of diacetyl, 2, 3-pentanedione, and acetoin using respiratory tract vapor uptake models
Dose-response assessment of inhaled vapors demonstrates the utility of dosimetry models for interspecies extrapolation and chemical comparisons and how their use is an important part of risk characterization as non-animal alternatives are more widely considered.
Authors
- N. Sadekar (ORCID: https://orcid.org/0000-0002-8329-3720)
- Owen Price (ORCID: https://orcid.org/0000-0002-0726-7424)
- Julia S. Kimbell (ORCID: https://orcid.org/0000-0002-1969-6373)
- Bahman Asgharian (ORCID: https://orcid.org/0000-0001-9546-4534)
- Madhuri Singal (ORCID: https://orcid.org/0000-0001-9826-0836)
- Jeffry D. Schroeter
- Danielle Bothelo
Institutions
- University of North Carolina at Chapel Hill (US)
- Research Institute for Fragrance Materials (US)
- Laboratoire d'Aérologie (FR)
- University Dermatology (US)
- Applied Research Associates (United States) (US)
- Applied Research Associates (NZ)
Publication Details
- Journal
- Inhalation Toxicology
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1080/08958378.2025.2471086
- Primary Topic
- Advanced Chemical Sensor Technologies
- Type
- article
- Field-Weighted Citation Impact
- 0.00