PPARα regulates YAP protein levels and activity by affecting its ubiquitination modification
These findings highlight the pivotal role of ubiquitination in regulating YAP through PPARα activation, providing novel insights for future studies on the post-translational regulation of YAP by PPARα activation.
Authors
- Huichang Bi (ORCID: https://orcid.org/0000-0001-7094-2296)
- Shuaishuai Zhang (ORCID: https://orcid.org/0000-0002-1441-4840)
- Qianming Chen (ORCID: https://orcid.org/0000-0002-5371-4432)
- Linhu Ye (ORCID: https://orcid.org/0000-0002-9200-4409)
- Shicheng Fan (ORCID: https://orcid.org/0000-0003-3236-3765)
- Yang Xiao (ORCID: https://orcid.org/0000-0002-9297-0973)
- Guofang Bi (ORCID: https://orcid.org/0009-0004-5136-0388)
- Xiaowen Jiang (ORCID: https://orcid.org/0000-0002-4515-6266)
- Ziqi Chen (ORCID: https://orcid.org/0000-0002-3512-1190)
- Manlan Guo
- Jian-Hong Fang
- Wenhong Zhou
Institutions
- Peking University (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s12915-025-02163-5
- Citations
- 1
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- National Natural Science Foundation of China
- Guangdong Medical Research Foundation
- National Key Research and Development Program of China
- Basic and Applied Basic Research Foundation of Guangdong Province